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Outputs

Research Papers

2019
  • Witika, B.A.; Walker, R.B. Development, manufacture and characterization of niosomes for the delivery for nevirapine. Pharmazie 2019, 74, 91–96, doi:10.1691/ph.2019.8168.

2020
  • Witika, B.A.; Smith, V.J.; Walker, R.B. A comparative study of the effect of different stabilizers on the critical quality attributes of self-assembling nano co-crystals. Pharmaceutics 2020, 12, 1–15, doi:10.3390/pharmaceutics12020182.

  • Witika, B.A.; Smith, V.J.; Walker, R.B. Quality by design optimization of cold sonochemical synthesis of zidovudine-lamivudine nanosuspensions. Pharmaceutics 2020, 12, 1–20, doi:10.3390/pharmaceutics12040367.

  • Witika, B.A.; Makoni, P.A.; Matafwali, S.K.; Chabalenge, B.; Mwila, C.; Kalungia, A.C.; Nkanga, C.I.; Bapolisi, A.M.; Walker, R.B. Biocompatibility of Biomaterials for Nanoencapsulation: Current Approaches. Nanomaterials 2020, 1–45, doi:10.3390/nano10091649.

  • Mudenda, S.; Witika, B.A.; Sadiq, M.J.; Banda, M.; Mfune, R.L.; Daka, V.; Kalui, D.; Phiri, M.N.; Kasanga, M.; Mudenda, F.; et al. Self-medication and its Consequences during & after the Coronavirus Disease 2019 (COVID-19) Pandemic: A Global Health Problem. Eur. J. Environ. Public Heal. 2020, 5, em0066, doi:10.29333/ejeph/9308.

  • Witika, B.A.; Makoni, P.A.; Mweetwa, L.L.; Ntemi, P. V; Chikukwa, M.T.R.; Matafwali, S.K.; Mwila, C.; Mudenda, S.; Katandula, J.; Walker, R.B. Nano-Biomimetic Drug Delivery Vehicles: Potential Approaches for COVID-19 Treatment. Molecules 2020, 25, 1–20, doi: 10.3390/molecules25245952.

2021
  • Witika, B.A.; Stander, J.; Smith, V.J.; Walker, R.B. Nano Co-Crystal Embedded Stimuli-Responsive Hydrogels: A Potential Approach to Treat HIV / AIDS. Pharmaceutics 2021, 13, 127, doi:10.3390/pharmaceutics13020127.

  • Witika, B.A.; Smith, V.J.; Walker, R.B. Top-Down Synthesis of a Lamivudine-Zidovudine Nano Co-Crystal. Crystals 2021, 11, 1–18, doi:10.3390/cryst11010033.

  • Witika, B.A.; Walker, R.B. Preformulation characterization and identification of excipients for nevirapine loaded niosomes. Pharmazie 2021, 7, 77–83, doi:10.1691/ph.2021.0137.

  • Witika, B.A.; Aucamp, M.; Mweetwa, L.L.; Makoni, P.A. Application of Fundamental Techniques for Physicochemical Characterizations to Understand Post-Formulation Performance of Pharmaceutical Nanocrystalline Materials. Crystals 2021, 11, 310, doi:10.3390/cryst11030310.

  • Mudenda, S.; Mukosha, M.; Mwila, C.; Saleem, Z.; Kalungia, A.C.; Munkombwe, D.; Daka, V.; Witika, B.A.; Kampamba, M.; Hikaambo, C.N.; et al. Impact of the coronavirus disease on the mental health and physical activity of pharmacy students at the University of Zambia: a cross-sectional study. Int. J. Basic Clin. Pharmacol. 2021, 10, 324, doi:10.18203/2319-2003.ijbcp20211010.

  • Witika, B.A.; Mweetwa, L.L.; Tshiamo, K.O.; Edler, K.; Matafwali, S.K.; Ntemi, P. V; Chikukwa, M.T.R.; Makoni, P.A. Vesicular drug delivery for the treatment of topical disorders: current and future perspectives. J. Pharm. Pharmacol. 2021, doi:10.1093/jpp/rgab082.

  • Witika, B.A.; Makoni, P.A.; Matafwali, S.K.; Mweetwa, L.L.; Shandele, G.C.; Walker, R.B. Enhancement of biological and pharmacological properties of an encapsulated polyphenol: Curcumin. Molecules 2021, doi:10.3390/molecules26144244

  • Matafwali, S.K.; Vlahakis, P.A.; Daka, V.; Witika, B.A.; Nyirenda, H.T.; Chisompola, N.K.; Mwila, C. Assessment of the availability of snakebite antivenom in health facilities in Ndola District, Zambia: a cross-sectional study. Trans. R. Soc. Trop. Med. Hyg. 2021, 1–3, doi:10.1093/trstmh/trab178.

  •  Buya, A.B.; Witika, B.A.; Bapolisi, A.M.; Mwila, C.; Mukubwa, G.K.; Memvanga, P.B.; Makoni, P.A.; Nkanga, C.I. Application of Lipid-Based Nanocarriers for Antitubercular Drug Delivery:A Review. Pharmaceutics 2021, 13, 2041, doi:10.3390/pharmaceutics13122041.

2022
  • Witika, B.A.; Poka, M.S.; Demana, P.H.; Matafwali, S.K.; Melamane, S.; Malungelo Khamanga, S.M.; Makoni, P.A. Lipid-Based Nanocarriers for Neurological Disorders: A Review of the State-of-the-Art and Therapeutic Success to Date. Pharmaceutics 2022, 14, 836, doi:10.3390/pharmaceutics14040836.

  • Kiyonga, E.M.; Kekani, L.N.; Chidziwa, T. V; Kahwenga, K.D.; Bronkhorst, E.; Milne, M.; Poka, M.S.; Mokhele, S.; Demana, P.H.; Witika, B.A. Nano-and Crystal Engineering Approaches in the Development of Therapeutic Agents for Neoplastic Diseases. Crystals 2022, 12, 926, doi:10.3390/cryst12070926.

  • Akombaetwa, N.; Bwanga, A.; Makoni, P.A.; Witika, B.A. Applications of Electrospun Drug-Eluting Nanofibers in Wound Healing: Current and Future Perspectives. Polymers (Basel). 2022, 14, 2931, doi:10.3390/polym14142931.

  • Dludla, S.B.K.; Mashabela, L.T.; Ng’andwe, B.; Makoni, P.A.; Witika, B.A. Current Advances in Nano-Based and Polymeric Stimuli-Responsive Drug Delivery Targeting the Ocular Microenvironment: A Review and Envisaged Future Perspectives. 2022, doi:10.3390/polym14173580.

  • Witika, B.A.; Bassey, K.E.; Demana, P.H.; Siwe-Noundou, X.; Poka, M.S. Current Advances in Specialised Niosomal Drug Delivery: Manufacture, Characterization and Drug Delivery Applications. 2022, doi:10.3390/ijms23179668.

  • Bassey, K.; Mabowe, M.; Mothibe, M.; Witika, B.A. Chemical Characterization and Nutritional Markers of South African Moringa Oleifera Seed Oils. Molecules 2022, 27, 5749, doi:10.3390/molecules2718574

  • Mashabela, L.T.; Maboa, M.M.; Miya, N.F.; Ajayi, T.O.; Chasara, R.S.; Milne, M.; Mokhele, S.; Demana, P.H.; Witika, B.A.; Siwe-Noundou, X.; et al. A Comprehensive Review of Cross-Linked Gels as Vehicles for Drug Delivery to Treat Central Nervous System Disorders. Gels 2022, 8, 563, doi:10.3390/gels8090563.

  • Mudenda, S.; Mukosha, M.; Nang’andu, C.; Meyer, C. J.; Fadare, J.; Kampamba, M.; Kalungia, A. C.; Munsaka, S.; Okoro, R. N.; Daka, V.; Chileshe, M.; Mfune, R. L.; Mufawambi, W.; Witika, B. A.; Godman, B. Awareness and Acceptance of COVID-19 Vaccines and Associated Factors among Pharmacy Students in Zambia. Malawian Med. J. 2022, 34 (September), 236–243. https://doi.org/10.4314/mmj.v34i3.

  • Xulu, J.H.; Ndongwe, T.; Ezealisiji, K.M.; Tembu, V.J.; Mncwangi, N.P.; Witika, B.A.; Noundou, X.S. The Use of Medicinal Plant ‐ Derived Metallic Nanoparticles in Theranostics. Pharmaceutics 2022, 14, 2437, doi:10.3390/pharmaceutics 14112437.

  • Mudenda, S.; Ngalande, N.; Mukosha, M.; Hikaambo, C.N.; Daka, V.; Matafwali, S.K.; Banda, M.; Mfune, R.L.; Mayoka, G.; Witika, B.A. Knowledge and practices toward COVID-19 among healthcare students: A cross-sectional study at the University of Zambia. Front. Public Heal. 2022, 0, 4658, doi:10.3389/FPUBH.2022.1028312

  • Poka, M.S.; Chanyandura, J.T.; Witika, B.A. Challenges faced by blind patients using chronic medication at a tertiary hospital in South Africa. Heal. SA Gesondheid 2022, 27, 1–7, doi:10.4102/hsag.v27i0.1900.

  • S. Mudenda, M. Mukosha, B. Godman, J.O. Fadare, O.O. Ogunleye, J.C. Meyer, P. Skosana, J. Chama, V. Daka, S.K. Matafwali, B. Chabalenge, B.A. Witika, Knowledge, Attitudes, and Acceptance of COVID-19 Vaccines among Secondary School Pupils in Zambia: Implications for Future Educational and Sensitisation Programmes, Vaccines. 10 (2022) 1–14. doi.org/10.3390/vaccines10122141.

2023
  • Ndongwe, T.; Witika, B.A.; Mncwangi, N.P.; Poka, M.S.; Skosana, P.P. Iridoid Derivatives as Anticancer Agents : An Updated Review from 1970 – 2022. Cancers (Basel). 2023, 15, 1–34, doi:10.3390/cancers15030770.

  • Makwela, A.B.; Grootboom, W.M.; Abraham, V.; Witika, B.A.; Godman, B.; Skosana, P.P. Antimicrobial Management of Skin and Soft Tissue Infections among Surgical Wards in South Africa: Findings and Implications. Antibiotics 2023, 12, 275, doi:10.3390/antibiotics12020275.

  • Akombaetwa, N.; Ilangala, A.B.; Thom, L.; Memvanga, P.B.; Witika, B.A.; Buya, A.B. Current Advances in Lipid Nanosystems Intended for Topical and Transdermal Drug Delivery Applications. Pharmaceutics 2023,15, 656, doi:10.3390/pharmaceutics1502065.

  • Witika, B.A.; Choonara, Y.E.; Demana, P.H. A SWOT analysis of nano co-crystals in drug delivery: present outlook and future perspectives. RSC Adv. 2023, 13, 7339–7351, doi:10.1039/d3ra00161j.

  • Kekani, L.N.; Witika, B.A. Current advances in nanodrug delivery systems for malaria prevention and treatment. Discov. Nano 2023, 18, doi:10.1186/s11671-023-03849-x.

  • Skosana, P.P.; Mudenda, S.; Demana, P.H.; Witika, B.A. Exploring Nanotechnology as a Strategy to Circumvent Antimicrobial Resistance in Bone and Joint Infections. ACS Omega 2023, doi:10.1021/acsomega.3c01225.

  • Masetla, M.A.; Ntuli, P.N.; Abraham, V.; Godman, B.; Witika, B.A.; Mudenda, S.; Skosana, P.P. Antimicrobial Stewardship for Outpatients with Chronic Bone and Joint Infections in the Orthopaedic Clinic of an Academic Tertiary Hospital, South Africa. Antibiotics 2023, 12, 1142, doi:10.3390/antibiotics12071142.

  • Mudenda, S.; Daka, V.; Matafwali, S.K.; Skosana, P.; Chabalenge, B.; Mukosha, M.; Fadare, J.O.; Mfune, R.L.; Witika, B.A.; Alumeta, M.G.; et al. COVID-19 Vaccine Acceptance and Hesitancy among Healthcare Workers in Lusaka , Zambia ; Findings and Implications for the Future. Vaccines 2023, 11, 1–18, doi:10.3390/vaccines11081350

  • Chasara, R.S.; Ajayi, T.O.; Leshilo, D.M.; Poka, M.S.; Witika, B.A. Exploring novel strategies to improve anti-tumour efficiency: The potential for targeting reactive oxygen species. Heliyon 2023, 9, e19896, doi:10.1016/j.heliyon.2023.e19896.

  • Mudenda, S., Meyer, J.C., Fadare, J.O., Ogunleye, O.O., Saleem, Z., Matafwali, S.K., Daka, V., 10, I.D., Chabalenge, B., Chama, J., Mukosha, M., Skosana, P., Witika, B.A., Kalungia, A.C., Hamachila, A., Mufwambi, W., Godman, B., 2023. COVID-19 vaccine uptake and associated factors among adolescents and youths: Findings and implications for future vaccination programmes. PLOS Glob. Public Heal. 3, e0002385. https://doi.org/10.1371/JOURNAL.PGPH.0002385

  • Lukhele, B.S.; Bassey, K.; Witika, B.A. The Utilization of Plant-Material-Loaded Vesicular Drug Delivery Systems in the Management of Pulmonary Diseases. Curr. Issues Mol. Biol. 2023, 45, 9985–10017, doi:10.3390/CIMB45120624.

2024
  • Ajayi, T.O.; Poka, M.S.; Witika, B.A. Formulation and optimisation of bedaquiline nanoemulsions for the potential treatment of multi drug resistant tuberculosis in paediatrics using quality by design. Sci. Rep. 2024, 14, 31891, doi:10.1038/s41598-024-83408-1.

  • Witika, B.A.; Hutton, A.; Makoni, P.A.; Donnelly, R.F. A State-of-the-Art Appraisal of Nanomaterials in Microneedles in the Delivery of Therapeutics and Vaccines. Adv. NanoBiomed Res. 2024, 2400162, doi:10.1002/anbr.202400162.

  • Ajayi, T.O.; Poka, M.S.; Witika, B.A. Nanotechnological Innovations in Paediatric Tuberculosis Management: Current Trends and Future Prospects. Front. Drug Deliv. 2024, 3, 1–19, doi:10.3389/fddev.2023.1295815..

  • Kasali, F.M.; Kadima, J.N.; Safari, J.B.; Agaba, A.G.; Tusiimire, J.; Witika, B.A. Effects of Physalis Peruviana L. (Leaf Crude Extracts) on Blood Glucose and Functional Biomarkers in Streptozotocin-Nicotinamide-Induced Diabetic Rats. Pharmazie 2024, 79, 6–10, doi:10.1691/ph.2024.3640.

  • Ajayi, T.O.; Poka, M.S.; Witika, B.A. Development of Bedaquiline Nanoemulsions Intended for Paediatric Multidrug-Resistant Tuberculosis: Excipient Selection and Preformulation Studies. Front. Med. Technol. 2024 6, 1388113, doi:10.3389/fmedt.2024.1388113.

  • Buya, A.B.; Mahlangu, P.; Witika, B.A. From Lab to Industrial Development of Lipid Nanocarriers Using Quality by Design Approach. Int. J. Pharm. X 2024, 8, 100266, doi:10.1016/J.IJPX.2024.100266.

  • Andrew, J.; Ezra-Manicum, A.-L.; Witika, B.A. Developments in radionanotheranostic strategies for precision diagnosis and treatment of prostate cancer. EJNMMI Radiopharm. Chem. 2024 91 2024, 9, 1–27, doi:10.1186/S41181-024-00295-7.

  • Ndongwe, T.; Zhou, A.-A.; Ganga, N.P.; Matawo, N.; Sibanda, U.; Chidziwa, T.V.; Witika, B.A.; Krause, R.W.M.; Matlou, G.G.; Siwe-Noundou, X. The use of nanomaterials as drug delivery systems and anticancer agents in the treatment of triple-negative breast cancer: an updated review (year 2005 to date). Discov. Nano 2024 191 2024, 19, 1–24, doi:10.1186/S11671-024-04089-3.

  • Ajayi, T.O.; Poka, M.S.; Witika, B.A. Method development and validation of an analytical quality by design ultrafast liquid chromatographic method for the determination of bedaquiline from pharmaceutical bulk and nanoemulsions. Biomed. Chromatogr. 2024, e6037, doi:10.1002/bmc.6037

2025
  • Sebatana, R.; Kudzai, K.D.; Magura, A.; Mdlophane, A.; Zeevaart, J.R.; Sathekge, M.; Kahts, M.; Mdanda, S.; Witika, B.A. An Insight to Nanoliposomes as Smart Radiopharmaceutical Delivery Tools for Imaging Atherosclerotic Plaques: Positron Emission Tomography Applications. Pharmaceutics 2025, 17, 240. https://doi.org/10.3390/pharmaceutics17020240

Book Chapters

2023

  • Andrew, J.; Amuchilani, W.; Mweetwa, L.L.; Fundafunda, S. V.; Poka, M.S.; Witika, B.A. Nanotheranostic applications in the detection and treatment of cervical cancer. In Nanotechnology Principles in Drug Targeting and Diagnosis; Elsevier, 2023; pp. 413–430.

  • Witika, B.A.; Matafwali, S.K.; Makoni, P.A. Macrophage-mimetic nanomedicines for the treatment of diseases. In Nanotechnology Principles in Drug Targeting and Diagnosis; Elsevier, 2023; pp. 63–89.

  • Melamane, S.; Manadava, T.T.; Manda, A.; Luphade, N.; Khamanga, S.M.M.; Makoni, P.A.; Demana, P.H.; Matafwali, S.K.; Witika, B.A. Artificial neural network–based inference of drug–target interactions. In Nanotechnology Principles in Drug Targeting and Diagnosis; Elsevier, 2023; pp. 35–62.

2025

  • Witika, B.A.; Poka, M.S.; Makoni, P.A.; Ramazani, F.; Nkanga, C.I. Clinical Applications of Long Acting Injectables: Systemic and Local Drug Delivery. In Biodegradable Long Acting Injectables and Implants: An Industry View; Ramazani, F., Ed.; Springer Nature Switzerland: Cham, 2025; pp. 185–220 ISBN 978-3-031-72302-5.

Intellectual Property

2024

Preparation of a Raloxifene Hydrate  for Cancer and Osteoporosis Therapy. SA/2024/02995

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